Altered lipid composition in Streptococcus pneumoniae cpoA mutants.

ABSTRACT:

Background

Penicillin-resistance in Streptococcus pneumoniae is mainly due to alterations in genes encoding the target enzymes for beta-lactams, the penicillin-binding proteins (PBPs). However, non-PBP genes are altered in beta-lactam-resistant laboratory mutants and confer decreased susceptibility to beta-lactam antibiotics. Two piperacillin resistant laboratory mutants of Streptococcus pneumoniae R6 contain mutations in the putative glycosyltransferase gene cpoA. The CpoA gene is part of an operon including another putative glycosyltransferase gene spr0982, both of which being homologous to glycolipid synthases present in other Gram-positive bacteria.

Results

We now show that the cpoA mutants as well as a cpoA deletion mutant are defective in the synthesis of galactosyl-gl

SUBMITTER: Meiers M 

PROVIDER: S-EPMC3901891 | biostudies-literature | 2014 Jan

REPOSITORIES: biostudies-literature