Risk miRNA screening of ovarian cancer based on miRNA functional synergistic network.

ABSTRACT:

Background

miRNAs are proved to have causal roles in tumorgenesis involving various types of human cancers, but the mechanism is not clear. We aimed to explore the effect of miRNAs on the development of ovarian cancer and the underlying mechanism.

Methods

The miRNA expression profile GSE31801 was downloaded from GEO (Gene Expression Omnibus) database. Firstly, the differentially expressed miRNAs were screened. Target genes of the miRNAs were collected from TargetScan, PicTar, miRanda, and DIANA-microT database, then the miRNA-miRNA co-regulating network was constructed using miRNA pairs with common regulated target genes. Next, the functional modules in the network were studied, the miRNA pairs regulated at least one modules were enriched to form the miRNA functional synergi

SUBMITTER: Ying H 

PROVIDER: S-EPMC3902002 | biostudies-literature | 2014 Jan

REPOSITORIES: biostudies-literature