A role of ADAR2 and RNA editing of glutamate receptors in mood disorders and schizophrenia.

ABSTRACT:

Background

Pre-mRNAs of 2-amino-3-(3-hydroxy-5-methyl-isoxazol-4-yl)-propanoic acid (AMPA)/kainate glutamate receptors undergo post-transcriptional modification known as RNA editing that is mediated by adenosine deaminase acting on RNA type 2 (ADAR2). This modification alters the amino acid sequence and function of the receptor. Glutamatergic signaling has been suggested to have a role in mood disorders and schizophrenia, but it is unknown whether altered RNA editing of AMPA/kainate receptors has pathophysiological significance in these mental disorders. In this study, we found that ADAR2 expression tended to be decreased in the postmortem brains of patients with schizophrenia and bipolar disorder.

Results

Decreased ADAR2 expression was significantly correlated with decrease

SUBMITTER: Kubota-Sakashita M 

PROVIDER: S-EPMC3902024 | biostudies-literature | 2014 Jan

REPOSITORIES: biostudies-literature