Efficacy of coupled plasma filtration adsorption (CPFA) in patients with septic shock: a multicenter randomised controlled clinical trial.

ABSTRACT:

Objectives

Coupled plasma filtration adsorption (CPFA, Bellco, Italy), to remove inflammatory mediators from blood, has been proposed as a novel treatment for septic shock. This multicenter, randomised, non-blinded trial compared CPFA with standard care in the treatment of critically ill patients with septic shock.

Design

Prospective, multicenter, randomised, open-label, two parallel group and superiority clinical trial.

Setting

18 Italian adult, general, intensive care units (ICUs).

Participants

Of the planned 330 adult patients with septic shock, 192 were randomised to either have CPFA added to the standard care, or not. The external monitoring committee excluded eight ineligible patients who were erroneously included.

Interventions

CPFA was to be perf

SUBMITTER: Livigni S 

PROVIDER: S-EPMC3902195 | biostudies-literature | 2014 Jan

REPOSITORIES: biostudies-literature