Single nucleotide polymorphisms in uracil-processing genes, intake of one-carbon nutrients and breast cancer risk.

ABSTRACT:

Background/objectives

The misincorporation of uracil into DNA leads to genomic instability. In a previous study, some of us identified four common single nucleotide polymorphisms (SNPs) in uracil-processing genes (rs2029166 and rs7296239 in SMUG1, rs34259 in UNG and rs4775748 in DUT) that were associated with significantly altered levels of uracil in human DNA. We investigated whether any of these SNPs are associated with an altered risk of developing breast cancer and if one-carbon nutrients intake can modify their effects.

Subjects/methods

We genotyped the four SNPs in 1077 cases of incident breast cancer and 1910 age and race-matched controls in the Western New York Exposures and Breast Cancer (WEB) Study and examined associations with breast cancer risk and interactions

SUBMITTER: Marian C 

PROVIDER: S-EPMC3902360 | biostudies-literature | 2011 Jun

REPOSITORIES: biostudies-literature