Alterations in hepatic miRNA expression during negative energy balance in postpartum dairy cattle.

ABSTRACT:

Background

Negative energy balance (NEB), an altered metabolic state, occurs in early postpartum dairy cattle when energy demands to support lactation exceed energy intake. During NEB the liver undergoes oxidative stress and increased breakdown of fatty acids accompanied by changes in gene expression. It is now known that micro RNAs (miRNA) can have a role in mediating such alterations in gene expression through repression or degradation of target mRNAs. miRNA expression is known to be altered by metabolism and environmental factors and miRNAs are implicated in expression modulation of metabolism related genes.

Results

miRNA expression was profiled in the liver of moderate yielding dairy cattle under severe NEB (SNEB) and mild NEB (MNEB) using the Affymetrix Gene Chip miRNA_

SUBMITTER: Fatima A 

PROVIDER: S-EPMC3902422 | biostudies-literature | 2014 Jan

REPOSITORIES: biostudies-literature