Age at surgical menopause influences cognitive decline and Alzheimer pathology in older women.

ABSTRACT:

Objective

To determine the association between age at surgical menopause and both cognitive decline and Alzheimer disease (AD) pathology in 2 longitudinal cohorts.

Methods

Female subjects from 2 longitudinal studies of cognitive decline (Religious Orders Study and Rush Memory and Aging Project) were included (total n = 1,884). The primary analysis examined the association between age at surgical menopause and decline in a global cognition score. Secondary analyses examined additional outcomes: 1) decline in 5 cognitive subdomains and 2) a global measure of the burden of AD pathology. In exploratory analyses, we examined the effect of hormone replacement therapy (HRT). We adjusted all models for age, education, smoking, and cohort and stratified by surgical vs natural menopau

SUBMITTER: Bove R 

PROVIDER: S-EPMC3902759 | biostudies-literature | 2014 Jan

REPOSITORIES: biostudies-literature