Prediction of postchemotherapy ovarian function using markers of ovarian reserve.

ABSTRACT:

Background

Reproductive-aged women frequently receive both chemotherapy and endocrine therapy as part of their treatment regimen for early stage hormone receptor-positive breast cancer. Chemotherapy results in transient or permanent ovarian failure in the majority of women. The difficulty in determining which patients will recover ovarian function has implications for adjuvant endocrine therapy decision making. We hypothesized that pretreatment serum anti-Müllerian hormone (AMH) and inhibin B concentrations would predict for ovarian function following chemotherapy.

Methods

Pre- and perimenopausal women aged 25-50 years with newly diagnosed breast cancer were enrolled. Subjects underwent phlebotomy for assessment of serum AMH, inhibin B, follicle-stimulating hormone, and estr

SUBMITTER: Henry NL 

PROVIDER: S-EPMC3903057 | biostudies-literature | 2014 Jan

REPOSITORIES: biostudies-literature