Ontology highlight
ABSTRACT:
SUBMITTER: van Eijk MJ
PROVIDER: S-EPMC390319 | biostudies-literature | 2004 Mar
REPOSITORIES: biostudies-literature
Nucleic acids research 20040305 4
Scalable multiplexed amplification technologies are needed for cost-effective large-scale genotyping of genetic markers such as single nucleotide polymorphisms (SNPs). We present SNPWave, a novel SNP genotyping technology to detect various subsets of sequences in a flexible fashion in a fixed detection format. SNPWave is based on highly multiplexed ligation, followed by amplification of up to 20 ligated probes in a single PCR. Depending on the multiplexing level of the ligation reaction, the lat ...[more]