New insights into dissemination and variation of the health care-associated pathogen Acinetobacter baumannii from genomic analysis.

ABSTRACT:

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Acinetobacter baumannii is a globally important nosocomial pathogen characterized by an increasing incidence of multidrug resistance. Routes of dissemination and gene flow among health care facilities are poorly resolved and are important for understanding the epidemiology of A. baumannii, minimizing disease transmission, and improving patient outcomes. We used whole-genome sequencing to assess diversity and genome dynamics in 49 isolates from one United States hospital system during one year from 2007 to 2008. Core single-nucleotide-variant-based phylogenetic analysis revealed multiple founder strains and multiple independent strains recovered from the same patient yet was insufficient to fully resolve strain relationships, where gene content and insertion sequence patt

SUBMITTER: Wright MS 

PROVIDER: S-EPMC3903280 | biostudies-literature | 2014 Jan

REPOSITORIES: biostudies-literature