Epigenetic repression of herpes simplex virus infection by the nucleosome remodeler CHD3.

ABSTRACT:

Unlabelled

Upon infection, the genome of herpes simplex virus is rapidly incorporated into nucleosomes displaying histone modifications characteristic of heterochromatic structures. The initiation of infection requires complex viral-cellular interactions that ultimately circumvent this repression by utilizing host cell enzymes to remove repressive histone marks and install those that promote viral gene expression. The reversion of repression and activation of viral gene expression is mediated by the cellular coactivator HCF-1 in association with histone demethylases and methyltransferases. However, the mechanisms and the components that are involved in the initial repression remain unclear. In this study, the chromatin remodeler chromodomain helicase DNA binding (CHD3) protein is i

SUBMITTER: Arbuckle JH 

PROVIDER: S-EPMC3903285 | biostudies-literature | 2014 Jan

REPOSITORIES: biostudies-literature