DNA polymorphisms and response to treatment in patients with chronic hepatitis C: results from the HALT-C trial.

ABSTRACT:

Background/aims

Certain host genetic polymorphisms reportedly affect the likelihood of a sustained virological response (SVR) to interferon treatment in subjects infected with hepatitis C virus (HCV). As part of the HALT-C trial we evaluated genetic associations among patients infected with HCV genotype 1 who had failed previous interferon treatment.

Methods

SVR was determined 24 weeks after completing treatment with pegylated interferon alfa-2a and ribavirin. Eight single nucleotide polymorphisms (SNPs) were selected on the basis of previously reported associations with treatment response. Genotypes were assessed by polymerase chain reaction-based assays. The percentage of patients who achieved SVR was determined for each genotype and for an IL10 promoter diplotype.

Resu

SUBMITTER: Morgan TR 

PROVIDER: S-EPMC3903339 | biostudies-literature | 2008 Oct

REPOSITORIES: biostudies-literature