Adopting nested case-control quota sampling designs for the evaluation of risk markers.

ABSTRACT: Two-phase study methods, in which more detailed or more expensive exposure information is only collected on a sample of individuals with events and a small proportion of other individuals, are expected to play a critical role in biomarker validation research. One major limitation of standard two-phase designs is that they are most conveniently employed with study cohorts in which information on longitudinal follow-up and other potential matching variables is electronically recorded. However for many practical situations, at the sampling stage such information may not be readily available for every potential candidates. Study eligibility needs to be verified by reviewing information from medical charts one by one. In this manuscript, we study in depth a novel study design commonly undertake

SUBMITTER: Zheng Y 

PROVIDER: S-EPMC3903399 | biostudies-literature | 2013 Oct

REPOSITORIES: biostudies-literature