Systematic review, network meta-analysis and economic evaluation of biological therapy for the management of active psoriatic arthritis.

ABSTRACT:

Background

An updated economic evaluation was conducted to compare the cost-effectiveness of the four tumour necrosis factor (TNF)-α inhibitors adalimumab, etanercept, golimumab and infliximab in active, progressive psoriatic arthritis (PsA) where response to standard treatment has been inadequate.

Methods

A systematic review was conducted to identify relevant, recently published studies and the new trial data were synthesised, via a Bayesian network meta-analysis (NMA), to estimate the relative efficacy of the TNF-α inhibitors in terms of Psoriatic Arthritis Response Criteria (PsARC) response, Health Assessment Questionnaire (HAQ) scores and Psoriasis Area and Severity Index (PASI). A previously developed economic model was updated with the new meta-analysis results and cur

SUBMITTER: Cawson MR 

PROVIDER: S-EPMC3903562 | biostudies-literature | 2014 Jan

REPOSITORIES: biostudies-literature