The effect of souvenaid on functional brain network organisation in patients with mild Alzheimer's disease: a randomised controlled study.

ABSTRACT:

Background

Synaptic loss is a major hallmark of Alzheimer's disease (AD). Disturbed organisation of large-scale functional brain networks in AD might reflect synaptic loss and disrupted neuronal communication. The medical food Souvenaid, containing the specific nutrient combination Fortasyn Connect, is designed to enhance synapse formation and function and has been shown to improve memory performance in patients with mild AD in two randomised controlled trials.

Objective

To explore the effect of Souvenaid compared to control product on brain activity-based networks, as a derivative of underlying synaptic function, in patients with mild AD.

Design

A 24-week randomised, controlled, double-blind, parallel-group, multi-country study.

Participants

179 drug-naïve mil

SUBMITTER: de Waal H 

PROVIDER: S-EPMC3903587 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature