Silencing motifs in the Clr2 protein from fission yeast, Schizosaccharomyces pombe.

ABSTRACT: The fission yeast, Schizosaccharomyces pombe, is a well-established model for heterochromatin formation, but the exact sequence of events for initiation remains to be elucidated. The essential factors involved include RNA transcribed from repeated sequences together with the methyltransferase Clr4. In addition, histone deacetylases, like Clr3, found in the SHREC complex are also necessary for transcriptional silencing. Clr2 is another crucial factor required for heterochromatin formation found in the SHREC complex. The function of Clr2 has been difficult to establish due to the lack of conserved domains or homology to proteins of known molecular function. Using a bioinformatics approach, three conserved motifs in Clr2 were identified, which contained amino acids important for transcription

SUBMITTER: Steinhauf D 

PROVIDER: S-EPMC3903592 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature