Molecular library synthesis using complex substrates: expanding the framework of triterpenoids.

ABSTRACT: The remodeling of a natural product core framework by means of diversity-oriented synthesis (DOS) is a valuable approach to access diverse/biologically relevant chemical space and to overcome the limitations of combinatorial-type compounds. Here we provide proof of principle and a thorough conformational analysis for a general strategy whereby the inherent complexity of a starting material is used to define the regio- and stereochemical outcomes of reactions in chemical library construction. This is in contrast to the traditional DOS logic employing reaction development and catalysis to drive library diversity.

SUBMITTER: Ignatenko VA 

PROVIDER: S-EPMC3903665 | biostudies-literature | 2013 Jan

REPOSITORIES: biostudies-literature