Non-redundant unique interface structures as templates for modeling protein interactions.

ABSTRACT: Improvements in experimental techniques increasingly provide structural data relating to protein-protein interactions. Classification of structural details of protein-protein interactions can provide valuable insights for modeling and abstracting design principles. Here, we aim to cluster protein-protein interactions by their interface structures, and to exploit these clusters to obtain and study shared and distinct protein binding sites. We find that there are 22604 unique interface structures in the PDB. These unique interfaces, which provide a rich resource of structural data of protein-protein interactions, can be used for template-based docking. We test the specificity of these non-redundant unique interface structures by finding protein pairs which have multiple binding sites. We sug

SUBMITTER: Cukuroglu E 

PROVIDER: S-EPMC3903793 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature