Budget constraint and vaccine dosing: a mathematical modelling exercise.

ABSTRACT:

Background

Increasing the number of vaccine doses may potentially improve overall efficacy. Decision-makers need information about choosing the most efficient dose schedule to maximise the total health gain of a population when operating under a constrained budget. The objective of this study is to identify the most efficient vaccine dosing schedule within a fixed vaccination budget from a healthcare payer perspective.

Methods

An optimisation model is developed in which maximizing the disease reduction is the functional objective and the constraint is the vaccination budget. The model allows variation in vaccination dosing numbers, in cost difference per dose, in vaccine coverage rate, and in vaccine efficacy. We apply the model using the monovalent rotavirus vaccine as an e

SUBMITTER: Standaert BA 

PROVIDER: S-EPMC3904011 | biostudies-literature | 2014 Jan

REPOSITORIES: biostudies-literature