Association between ABCB1-T1236C polymorphism and drug-resistant epilepsy in Iranian female patients.

ABSTRACT:

Background

One third of epileptic patients are resistant to several anti-epileptic drugs (AED). P-glycoprotein (P-gp) is an efflux transporter encoded by ATP-binding cassette subfamily B member 1 (ABCB1) gene that excludes drugs from the cells and plays a significant role in AEDs resistance. Over-expression of P-gp could be a result of polymorphisms in ABCB1 gene. We studied the association of T129C and T1236C single-nucleotide polymorphisms (SNP) of ABCB1 gene with drug-resistant epilepsy in Iranian epileptics.

Methods

DNA samples were obtained from 200 healthy controls and 332 epileptic patients, of whom 200 were drug responsive and 132 drug resistant. The frequencies of the genotypes of the two SNP were determined by polymerase chain reaction followed by restriction fragm

SUBMITTER: Maleki M 

PROVIDER: S-EPMC3904059 | biostudies-literature | 2010 Jul

REPOSITORIES: biostudies-literature