Genetic variants associated with angiotensin-converting enzyme inhibitor-associated angioedema.

ABSTRACT:

Objective

The objective of this study was to identify genetic variants associated with angiotensin-converting enzyme (ACE) inhibitor-associated angioedema.

Participants and methods

We carried out a genome-wide association study in 175 individuals with ACE inhibitor-associated angioedema and 489 ACE inhibitor-exposed controls from Nashville (Tennessee) and Marshfield (Wisconsin). We tested for replication in 19 cases and 57 controls who participated in Ongoing Telmisartan Alone and in Combination with Ramipril Global Endpoint Trial (ONTARGET).

Results

There were no genome-wide significant associations of any single-nucleotide polymorphism (SNP) with angioedema. Sixteen SNPs in African Americans and 41 SNPs in European Americans were associated moderately with angioedem

SUBMITTER: Pare G 

PROVIDER: S-EPMC3904664 | biostudies-literature | 2013 Sep

REPOSITORIES: biostudies-literature