Fully automated segmentation of the pons and midbrain using human T1 MR brain images.

ABSTRACT:

Purpose

This paper describes a novel method to automatically segment the human brainstem into midbrain and pons, called labs: Landmark-based Automated Brainstem Segmentation. LABS processes high-resolution structural magnetic resonance images (MRIs) according to a revised landmark-based approach integrated with a thresholding method, without manual interaction.

Methods

This method was first tested on morphological T1-weighted MRIs of 30 healthy subjects. Its reliability was further confirmed by including neurological patients (with Alzheimer's Disease) from the ADNI repository, in whom the presence of volumetric loss within the brainstem had been previously described. Segmentation accuracies were evaluated against expert-drawn manual delineation. To evaluate the quality of L

SUBMITTER: Nigro S 

PROVIDER: S-EPMC3904850 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature