Dexamethasone exacerbates cerebral edema and brain injury following lithium-pilocarpine induced status epilepticus.

ABSTRACT: Anti-inflammatory therapies are the current most plausible drug candidates for anti-epileptogenesis and neuroprotection following prolonged seizures. Given that vasogenic edema is widely considered to be detrimental for outcome following status epilepticus, the anti-inflammatory agent dexamethasone is sometimes used in clinic for alleviating cerebral edema. In this study we perform longitudinal magnetic resonance imaging in order to assess the contribution of dexamethasone on cerebral edema and subsequent neuroprotection following status epilepticus. Lithium-pilocarpine was used to induce status epilepticus in rats. Following status epilepticus, rats were either post-treated with saline or with dexamethasone sodium phosphate (10mg/kg or 2mg/kg). Brain edema was assessed by means of magneti

SUBMITTER: Duffy BA 

PROVIDER: S-EPMC3905166 | biostudies-literature | 2014 Mar

REPOSITORIES: biostudies-literature