A novel computational biostatistics approach implies impaired dephosphorylation of growth factor receptors as associated with severity of autism.

ABSTRACT: The prevalence of autism spectrum disorders (ASDs) has increased 20-fold over the past 50 years to >1% of US children. Although twin studies attest to a high degree of heritability, the genetic risk factors are still poorly understood. We analyzed data from two independent populations using u-statistics for genetically structured wide-locus data and added data from unrelated controls to explore epistasis. To account for systematic, but disease-unrelated differences in (non-randomized) genome-wide association studies (GWAS), a correlation between P-values and minor allele frequency with low granularity data and for conducting multiple tests in overlapping genetic regions, we present a novel study-specific criterion for 'genome-wide significance'. From recent results in a comorbid disease, c

SUBMITTER: Wittkowski KM 

PROVIDER: S-EPMC3905234 | biostudies-literature | 2014 Jan

REPOSITORIES: biostudies-literature