Flow patterns regulate hyperglycemia-induced subendothelial matrix remodeling during early atherogenesis.

ABSTRACT:

Objective

Altered subendothelial matrix composition regulates endothelial dysfunction and early atherosclerotic plaque formation. Hyperglycemia promotes endothelial matrix remodeling associated with multiple microvascular complications of diabetes, but a role for altered matrix composition in diabetic atherogenesis has not been described. Therefore, we sought to characterize the alterations in matrix composition during diabetic atherogenesis using both in vitro and in vivo model systems.

Methods and results

Streptozotocin-induced diabetes in atherosclerosis-prone ApoE knockout mice promoted transitional matrix expression (fibronectin, thrombospondin-1) and deposition in intima of the aortic arch as determined by qRT-PCR array and immunohistochemistry. Early plaque formation

SUBMITTER: Green J 

PROVIDER: S-EPMC3905249 | biostudies-literature | 2014 Feb

REPOSITORIES: biostudies-literature