Genomic analysis of thermophilic Bacillus coagulans strains: efficient producers for platform bio-chemicals.

ABSTRACT: Microbial strains with high substrate efficiency and excellent environmental tolerance are urgently needed for the production of platform bio-chemicals. Bacillus coagulans has these merits; however, little genetic information is available about this species. Here, we determined the genome sequences of five B. coagulans strains, and used a comparative genomic approach to reconstruct the central carbon metabolism of this species to explain their fermentation features. A novel xylose isomerase in the xylose utilization pathway was identified in these strains. Based on a genome-wide positive selection scan, the selection pressure on amino acid metabolism may have played a significant role in the thermal adaptation. We also researched the immune systems of B. coagulans strains, which provide th

SUBMITTER: Su F 

PROVIDER: S-EPMC3905273 | biostudies-literature | 2014 Jan

REPOSITORIES: biostudies-literature