Relationship between obesity and depression: characteristics and treatment outcomes with antidepressant medication.

ABSTRACT:

Objective

Obesity and major depressive disorder often co-occur. However, differences between obese and normal-weight depressed patients and the moderating effect of obesity on antidepressant treatment outcome are not well studied.

Methods

Adults (n = 662) with major depressive disorder in the Combining Medications to Enhance Depression Outcomes study were randomized to treatment with escitalopram plus placebo, bupropion plus escitalopram, or venlafaxine plus mirtazapine for a 12-week primary treatment phase and 16-week follow-up. Body mass index (BMI) was calculated at baseline and categorized according to World Health Organization criteria: normal or low weight (NW), overweight, Obese I and Obese II+. A repeated-effects model, unadjusted and adjusted for baseline variables,

SUBMITTER: Toups MS 

PROVIDER: S-EPMC3905462 | biostudies-literature | 2013 Nov-Dec

REPOSITORIES: biostudies-literature