Targetome profiling, pathway analysis and genetic association study implicate miR-202 in lymphomagenesis.

ABSTRACT:

Background

miRNAs have been implicated in numerous tumorigenic pathways, and previous studies have associated miR-202 dysregulation with various cancer types, including follicular lymphoma.

Methods

The miR-202 targetome was identified by ribonucleoprotein immunoprecipitation-microarray (RIP-Chip), and functional interactions among identified targets were investigated using the Ingenuity Pathway Analysis tool. We also conducted a population-based genetic association study of a polymorphism within the miR-202 stem-loop sequence and risk of non-Hodgkin lymphoma. In vitro gain-of-function experiments were further conducted to elucidate the functional significance of the variant.

Results

A total of 141 potential members of the miR-202 targetome were identified by a transcr

SUBMITTER: Hoffman AE 

PROVIDER: S-EPMC3905613 | biostudies-literature | 2013 Mar

REPOSITORIES: biostudies-literature