Cost-effectiveness of asenapine in the treatment of bipolar disorder in Canada.

ABSTRACT:

Background

Bipolar disorder (BPD) is prevalent and is associated with a significant economic burden. Asenapine, the first tetracyclic antipsychotic approved in Canada for the treatment of BPD, has shown a comparable efficacy profile to other atypical antipsychotics. In addition, it is associated with a favourable metabolic profile and minimal weight gain potential. This study aimed to assess the economic impact of asenapine compared to olanzapine in the treatment of BPD in Canada.

Methods

A decision tree combined with a Markov model was constructed to assess the cost-utility of asenapine compared with olanzapine. The decision tree takes into account the occurrence of extrapyramidal symptoms (EPS), the probability of switching to a different antipsychotic, and the probability

SUBMITTER: Lachaine J 

PROVIDER: S-EPMC3905654 | biostudies-literature | 2014 Jan

REPOSITORIES: biostudies-literature