Ultrashort single-walled carbon nanotubes in a lipid bilayer as a new nanopore sensor.

ABSTRACT: An important issue in nanopore sensing is to construct stable and versatile sensors that can discriminate analytes with minute differences. Here we report a means of creating nanopores that comprise ultrashort single-walled carbon nanotubes inserted into a lipid bilayer. We investigate the ion transport and DNA translocation through single-walled carbon nanotube nanopores and find that our results are fundamentally different from previous studies using much longer single-walled carbon nanotubes. Furthermore, we utilize the new single-walled carbon nanotube nanopores to selectively detect modified 5-hydroxymethylcytosine in single-stranded DNA, which may have implications in screening specific genomic DNA sequences. This new nanopore platform can be integrated with many unique properties of

SUBMITTER: Liu L 

PROVIDER: S-EPMC3905707 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature