Ontology highlight
ABSTRACT:
SUBMITTER: Bolli N
PROVIDER: S-EPMC3905727 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Nature communications 20140101
Multiple myeloma is an incurable plasma cell malignancy with a complex and incompletely understood molecular pathogenesis. Here we use whole-exome sequencing, copy-number profiling and cytogenetics to analyse 84 myeloma samples. Most cases have a complex subclonal structure and show clusters of subclonal variants, including subclonal driver mutations. Serial sampling reveals diverse patterns of clonal evolution, including linear evolution, differential clonal response and branching evolution. Di ...[more]