Principles of self-organization in biological pathways: a hypothesis on the autogenous association of alpha-synuclein.

ABSTRACT: Previous evidence indicates that a number of proteins are able to interact with cognate mRNAs. These autogenous associations represent important regulatory mechanisms that control gene expression at the translational level. Using the catRAPID approach to predict the propensity of proteins to bind to RNA, we investigated the occurrence of autogenous associations in the human proteome. Our algorithm correctly identified binding sites in well-known cases such as thymidylate synthase, tumor suppressor P53, synaptotagmin-1, serine/ariginine-rich splicing factor 2, heat shock 70 kDa, ribonucleic particle-specific U1A and ribosomal protein S13. In addition, we found that several other proteins are able to bind to their own mRNAs. A large-scale analysis of biological pathways revealed that aggrega

SUBMITTER: Zanzoni A 

PROVIDER: S-EPMC3905859 | biostudies-literature | 2013 Dec

REPOSITORIES: biostudies-literature