Serum proteomic analysis identifies sex-specific differences in lipid metabolism and inflammation profiles in adults diagnosed with Asperger syndrome.

ABSTRACT:

Background

The higher prevalence of Asperger Syndrome (AS) and other autism spectrum conditions in males has been known for many years. However, recent multiplex immunoassay profiling studies have shown that males and females with AS have distinct proteomic changes in serum.

Methods

Here, we analysed sera from adults diagnosed with AS (males = 14, females = 16) and controls (males = 13, females = 16) not on medication at the time of sample collection, using a combination of multiplex immunoassay and shotgun label-free liquid chromatography mass spectrometry (LC-MSE). The main objective was to identify sex-specific serum protein changes associated with AS.

Results

Multiplex immunoassay profiling led to identification of 16 proteins that were significantly altered in AS

SUBMITTER: Steeb H 

PROVIDER: S-EPMC3905921 | biostudies-literature | 2014 Jan

REPOSITORIES: biostudies-literature