Increased risk of non-fatal myocardial infarction following testosterone therapy prescription in men.

ABSTRACT:

Background

An association between testosterone therapy (TT) and cardiovascular disease has been reported and TT use is increasing rapidly.

Methods

We conducted a cohort study of the risk of acute non-fatal myocardial infarction (MI) following an initial TT prescription (N = 55,593) in a large health-care database. We compared the incidence rate of MI in the 90 days following the initial prescription (post-prescription interval) with the rate in the one year prior to the initial prescription (pre-prescription interval) (post/pre). We also compared post/pre rates in a cohort of men prescribed phosphodiesterase type 5 inhibitors (PDE5I; sildenafil or tadalafil, N = 167,279), and compared TT prescription post/pre rates with the PDE5I post/pre rates, adjusting for potential confo

SUBMITTER: Finkle WD 

PROVIDER: S-EPMC3905977 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature