A tandem isomerization/prins strategy: iridium(III)/Bronsted acid cooperative catalysis.

ABSTRACT: Working together: A mild and efficient isomerization/protonation sequence generates pyran-fused indoles by cooperative catalysis between cationic iridium(III) and Bi(OTf)3 . Three distinct cyclization manifolds lead to the corresponding bioactive scaffolds in good yields. In addition, N-substituted indoles can be synthesized enantioselectively in the presence of a chiral phosphate.

SUBMITTER: Lombardo VM 

PROVIDER: S-EPMC3905988 | biostudies-literature | 2013 Dec

REPOSITORIES: biostudies-literature