Enantioselective N-heterocyclic carbene catalyzed annulation reactions with imidazolidinones.

ABSTRACT: Add acetic acid: A highly stereoselective N-heterocyclic carbene (NHC)-catalyzed formal [4+2] annulation between α,β-unsaturated aldehydes and imidazolidinones for the synthesis of imidazoles has been developed. Acetic acid serves as a key additive to achieve high chemoselectivity for the formal [4+2] annulation product.

SUBMITTER: McCusker EO 

PROVIDER: S-EPMC3905989 | biostudies-literature | 2013 Dec

REPOSITORIES: biostudies-literature