Starvation increases insulin sensitivity and reduces juvenile hormone synthesis in mosquitoes.

ABSTRACT:

Background

The interactions between the insulin signaling pathway (ISP) and juvenile hormone (JH) controlling reproductive trade-offs are well documented in insects. JH and insulin regulate reproductive output in mosquitoes; both hormones are involved in a complex regulatory network, in which they influence each other and in which the mosquito's nutritional status is a crucial determinant of the network's output. Previous studies reported that the insulin-TOR (target of rapamacyn) signaling pathway is involved in the nutritional regulation of JH synthesis in female mosquitoes. The present studies further investigate the regulatory circuitry that controls both JH synthesis and reproductive output in response to nutrient availability.

Methods

We used a combination of diet rest

SUBMITTER: Perez-Hedo M 

PROVIDER: S-EPMC3906049 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature