Intracellular growth of Mycobacterium avium subspecies and global transcriptional responses in human macrophages after infection.

ABSTRACT:

Background

Mycobacterium avium subsp. avium (Maa) and M. avium subsp. hominissuis (Mah) are environmental mycobacteria and significant opportunistic pathogens. Mycobacterium avium infections in humans and pigs are mainly due to Mah. It is not known whether this is caused by a difference in virulence or difference in exposure to the two subspecies. The aim of the present study was to investigate the ability of the M. avium subspecies to replicate intracellularly and to characterise the gene expression program triggered by infection of human primary macrophages.

Results

All isolates were able to invade and persist within human macrophages. However, intracellular replication was only evident in cells infected with the two Maa isolates. Transcriptional responses to the isolates

SUBMITTER: Agdestein A 

PROVIDER: S-EPMC3906092 | biostudies-literature | 2014 Jan

REPOSITORIES: biostudies-literature