Gene expression profiling of mesenteric lymph nodes from sheep with natural scrapie.

ABSTRACT:

Background

Prion diseases are characterized by the accumulation of the pathogenic PrPSc protein, mainly in the brain and the lymphoreticular system. Although prions multiply/accumulate in the lymph nodes without any detectable pathology, transcriptional changes in this tissue may reflect biological processes that contribute to the molecular pathogenesis of prion diseases. Little is known about the molecular processes that occur in the lymphoreticular system in early and late stages of prion disease. We performed a microarray-based study to identify genes that are differentially expressed at different disease stages in the mesenteric lymph node of sheep naturally infected with scrapie. Oligo DNA microarrays were used to identify gene-expression profiles in the early/middle (preclini

SUBMITTER: Filali H 

PROVIDER: S-EPMC3906094 | biostudies-literature | 2014 Jan

REPOSITORIES: biostudies-literature