Mathematical modeling of renal tubular glucose absorption after glucose load.

ABSTRACT: A partial differential Progressive Tubular Reabsorption (PTR) model, describing renal tubular glucose reabsorption and urinary glucose excretion following a glucose load perturbation, is proposed and fitted to experimental data from five subjects. For each subject the Glomerular Filtration Rate was estimated and both blood and urine glucose were sampled following an Intra-Venous glucose bolus. The PTR model was compared with a model representing the conventional Renal Threshold Hypothesis (RTH). A delay bladder compartment was introduced in both formulations. For the RTH model, the average threshold for glycosuria varied between 9.90 ± 4.50 mmol/L and 10.63 ± 3.64 mmol/L (mean ± Standard Deviation) under different hypotheses; the corresponding average maximal transport rates varied between

SUBMITTER: De Gaetano A 

PROVIDER: S-EPMC3906102 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature