Combining epidemiologic and biostatistical tools to enhance variable selection in HIV cohort analyses.

ABSTRACT:

Background

Variable selection is an important step in building a multivariate regression model for which several methods and statistical packages are available. A comprehensive approach for variable selection in complex multivariate regression analyses within HIV cohorts is explored by utilizing both epidemiological and biostatistical procedures.

Methods

Three different methods for variable selection were illustrated in a study comparing survival time between subjects in the Department of Defense's National History Study and the Atlanta Veterans Affairs Medical Center's HIV Atlanta VA Cohort Study. The first two methods were stepwise selection procedures, based either on significance tests (Score test), or on information theory (Akaike Information Criterion), while the third

SUBMITTER: Rentsch C 

PROVIDER: S-EPMC3906149 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature