Qualichem in vivo: a tool for assessing the quality of in vivo studies and its application for bisphenol A.

ABSTRACT: In regulatory toxicology, quality assessment of in vivo studies is a critical step for assessing chemical risks. It is crucial for preserving public health studies that are considered suitable for regulating chemicals are robust. Current procedures for conducting quality assessments in safety agencies are not structured, clear or consistent. This leaves room for criticism about lack of transparency, subjective influence and the potential for insufficient protection provided by resulting safety standards. We propose a tool called "Qualichem in vivo" that is designed to systematically and transparently assess the quality of in vivo studies used in chemical health risk assessment. We demonstrate its use here with 12 experts, using two controversial studies on Bisphenol A (BPA) that played an

SUBMITTER: Maxim L 

PROVIDER: S-EPMC3906223 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature