Ontology highlight
ABSTRACT:
SUBMITTER: Dimri M
PROVIDER: S-EPMC3906339 | biostudies-literature | 2013 Nov
REPOSITORIES: biostudies-literature
Dimri Manjari M Carroll Jeremy D JD Cho Joon-Ho JH Dimri Goberdhan P GP
Cell cycle (Georgetown, Tex.) 20130924 22
Polycomb group protein BMI1 is an important regulator of senescence, aging, and cancer. On one hand, it is overexpressed in cancer cells and is required for self-renewal of stem cells. On the other hand, it is downregulated during senescence and aging. MicroRNAs have emerged as major regulators of almost every gene associated with cancer, aging, and related pathologies. At present, very little is known about the miRNAs that regulate the expression of BMI1. Here, we report that miR-141 posttransc ...[more]