Naturally occurring IgG antibody levels to the Staphylococcus aureus protein IsdB in humans.

ABSTRACT: Staphylococcus aureus is a well-recognized, clinically important cause of nosocomial infections, and as such, a vaccine to prevent S. aureus infections would be an important achievement. A Phase IIB/III study of V710, a vaccine containing iron-regulated surface determinant B (IsdB), demonstrated significant sero-conversion rates in cardiovascular surgery patients following a single pre-surgery immunization. However, the vaccine was not efficacious in preventing bacteremia or deep sternal wound infection post-surgery, thus raising the possibility that IsdB might not be available for immune recognition during infection. The purpose of the work described herein was to evaluate and quantify the naturally occurring anti-IsdB levels at baseline and over time during infection, to understand wheth

SUBMITTER: Zorman JK 

PROVIDER: S-EPMC3906349 | biostudies-literature | 2013 Sep

REPOSITORIES: biostudies-literature