Preservation and compensation: the functional neuroanatomy of insight and working memory in schizophrenia.

ABSTRACT:

Background

Poor insight in schizophrenia has been theorised to reflect a cognitive deficit that is secondary to brain abnormalities, localized in the brain regions that are implicated in higher order cognitive functions, including working memory (WM). This study investigated WM-related neural substrates of preserved and poor insight in schizophrenia.

Method

Forty stable schizophrenia outpatients, 20 with preserved and 20 with poor insight (usable data obtained from 18 preserved and 14 poor insight patients), and 20 healthy participants underwent functional magnetic resonance imaging (fMRI) during a parametric 'n-back' task. The three groups were preselected to match on age, education and predicted IQ, and the two patient groups to have distinct insight levels. Performance an

SUBMITTER: Sapara A 

PROVIDER: S-EPMC3906535 | biostudies-literature | 2014 Jan

REPOSITORIES: biostudies-literature