Revised staging classification improves outcome prediction for small intestinal neuroendocrine tumors.

ABSTRACT:

Purpose

Small intestinal (SI) neuroendocrine tumors (NETs) have heterogeneous outcomes. The NET societies have recently proposed a TNM staging classification. In this study, we used population-based data to assess the validity of the staging system.

Patients and methods

We identified patients with SI-NETS diagnosed between 1988 and 2009 from the Surveillance, Epidemiology, and End Results registry. We used Kaplan-Meier analysis to assess disease-specific survival according to TNM status. Cox models were constructed to evaluate differences in prognosis after controlling for potential confounders.

Results

We identified 6,792 patients with SI-NET. Although the current staging system was predictive of prognosis, there was overlap among some groups (stage I/IIA, P = .36; s

SUBMITTER: Kim MK 

PROVIDER: S-EPMC3906571 | biostudies-literature | 2013 Oct

REPOSITORIES: biostudies-literature