Accelerated exon evolution within primate segmental duplications.

ABSTRACT:

Background

The identification of signatures of natural selection has long been used as an approach to understanding the unique features of any given species. Genes within segmental duplications are overlooked in most studies of selection due to the limitations of draft nonhuman genome assemblies and to the methodological reliance on accurate gene trees, which are difficult to obtain for duplicated genes.

Results

In this work, we detected exons with an accumulation of high-quality nucleotide differences between the human assembly and shotgun sequencing reads from single human and macaque individuals. Comparing the observed rates of nucleotide differences between coding exons and their flanking intronic sequences with a likelihood-ratio test, we identified 74 exons with eviden

SUBMITTER: Lorente-Galdos B 

PROVIDER: S-EPMC3906575 | biostudies-literature | 2013 Jan

REPOSITORIES: biostudies-literature