Proteomic analysis of aneurysm healing mechanism after coil embolization: comparison of dense packing with loose packing.

ABSTRACT:

Background and purpose

In clinical practice, durability of occlusion following coil embolization is superior in densely packed, compared with loosely packed, aneurysms. In a rabbit model, we probed, by using proteomics tools, the biologic mechanisms associated with densely packed and completely occluded aneurysms, compared with loosely packed and incompletely occluded aneurysms, to explore the biologic mechanisms of intra-aneurysmal healing following embolization.

Materials and methods

Elastase-induced, saccular aneurysms were created in 24 rabbits. Aneurysms were allowed to mature, after which aneurysms were either densely (packing attenuation >25%) or loosely (packing attenuation <20%) packed with platinum coils by endovascular means. After 2 weeks (n = 6 for both groups)

SUBMITTER: Kadirvel R 

PROVIDER: S-EPMC3906675 | biostudies-literature | 2012 Jun

REPOSITORIES: biostudies-literature