Dapagliflozin a glucose-regulating drug with diuretic properties in subjects with type 2 diabetes.

ABSTRACT:

Aims

Sodium-glucose co-transporter 2 (SGLT2) reabsorbs glucose and sodium in the renal proximal tubule. Dapagliflozin, an SGLT2 inhibitor, targets hyperglycaemia in type 2 diabetes by increasing renal glucose excretion. To investigate whether the parallel occurring sodium loss would have diuretic-like physiologic effects, we compared dapagliflozin and hydrochlorothiazide (HCTZ) effects on 24-h blood pressure (BP), body weight, plasma volume and glomerular filtration rate (GFR).

Methods

In this randomized, placebo-controlled, double-blind trial, 75 subjects with type 2 diabetes were assigned placebo, dapagliflozin 10 mg/day, or HCTZ 25 mg/day. Changes from baseline BP, body weight, plasma volume and GFR were assessed after 12 weeks of treatment.

Results

Subjects' mean

SUBMITTER: Lambers Heerspink HJ 

PROVIDER: S-EPMC3906841 | biostudies-literature | 2013 Sep

REPOSITORIES: biostudies-literature