Faster evolving Drosophila paralogs lose expression rate and ubiquity and accumulate more non-synonymous SNPs.

ABSTRACT:

Background

Duplicated genes can indefinately persist in genomes if either both copies retain the original function due to dosage benefit (gene conservation), or one of the copies assumes a novel function (neofunctionalization), or both copies become required to perform the function previously accomplished by a single copy (subfunctionalization), or through a combination of these mechanisms. Different models of duplication retention imply different predictions about substitution rates in the coding portion of paralogs and about asymmetry of these rates.

Results

We analyse sequence evolution asymmetry in paralogs present in 12 Drosophila genomes using the nearest non-duplicated orthologous outgroup as a reference. Those paralogs present in D. melanogaster are analysed in conju

SUBMITTER: Yampolsky LY 

PROVIDER: S-EPMC3906896 | biostudies-literature | 2014 Jan

REPOSITORIES: biostudies-literature